In recent years, remarkable progress has been made toward understanding the three-
dimensional (3D) organisation of genomes and the influence of genome organisation on …

Deconstructing the mechanism by which the 3D genome encodes genetic information to
generate diverse cell types during animal development is a major challenge in biology. The …

The genome of an early embryo undergoes significant remodelling at the epigenetic,
transcriptional, and structural levels. New technological developments have made it …

Chromatin looping plays an important role in genome regulation. However, because ChIP-
seq and loop-resolution Hi-C (DNA-DNA proximity ligation) are extremely challenging in …

In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

One of the most fundamental questions in developmental biology is how one fertilized cell
can give rise to a fully mature organism and how gene regulation governs this process …

Chromatin architecture mapping in 3D formats has increased our understanding of how
regulatory sequences and gene expression are connected and regulated in a genome. The …

At zygotic genome activation (ZGA), changes in chromatin structure are associated with new
transcription immediately following the maternal-to-zygotic transition (MZT). The nuclear …

Not only did the team find that genes regulated by super-enhancers occur within large
looped chromosome structures that are connected through interacting CTCF sites co …

The three-dimensional folding of chromosomes is essential for nuclear functions such as
DNA replication and gene regulation. The emergence of chromatin architecture is thus an …