DNA methylation is a major epigenetic modification; however, the precise role of DNA
methylation in vertebrate development is still not fully understood. Here, we show that DNA …

Mammalian genomes undergo epigenetic modifications, including cytosine methylation by
DNA methyltransferases (DNMTs). Oxidation of 5-methylcytosine by the Ten-eleven …

Although the human body appears superficially symmetrical with regard to the left–right (LR)
axis, most visceral organs are asymmetric in terms of their size, shape, or position. Such …

The specification of left–right asymmetry is an evolutionarily conserved developmental
process in vertebrates. The interplay between two TGFβ ligands, Derrière/GDF1 and …

Nodal is the major effector of left-right axis development. In mice, Nodal forms heterodimers
with Gdf1 and is inhibited by Cerl2/Dand5 at the node, and by Lefty1 in the lateral plate …

Left-right (LR) asymmetry is a fascinating problem in embryonic morphogenesis. Recently, a
pathway of genes has been identified which is involved in LR patterning in vertebrates …

In mammalian embryos, DNA methylation is initialized to maximum levels in the epiblast by
the de novo DNA methyltransferases DNMT3A and DNMT3B before gastrulation diversifies …

Background Members of the Dmrt family, generally associated with sex determination, were
shown to be involved in several other functions during embryonic development. Dmrt2 has …

Background Consistent asymmetry of the left-right (LR) axis is a crucial aspect of vertebrate
embryogenesis. Asymmetric gene expression of the TGFβ superfamily member Nodal …

DNA methylation and histone methylation are two key epigenetic modifications that help
govern heterochromatin dynamics. The roles for these chromatin-modifying activities in …