In mammalian cells, DNA methylation patterns are precisely maintained after DNA
replication with defined changes occurring during development. The major DNA …

Background In mammals, epigenetic information is established and maintained via the
postreplicative methylation of cytosine residues by the DNA methyltransferases Dnmt1 …

DNA methylation is an epigenetic modification of DNA. There are currently three catalytically
active mammalian DNA methyltransferases, DNMT1,-3a, and-3b. DNMT1 has been shown …

Abstract Background Though Dnmt1 is considered the primary maintenance
methyltransferase and Dnmt3a and Dnmt3b are considered de novo methyltransferases in …

In the cell, DNA is wrapped on histone octamers, which reduces its accessibility for DNA
interacting enzymes. We investigated de novo methylation of nucleosomal DNA in vitro and …

CpG methylation is involved in a wide range of biological processes in vertebrates as well
as in plants and fungi. To date, three enzymes, Dnmt1, Dnmt3a, and Dnmt3b, are known to …

DNA methylation is a major epigenetic modification and plays a crucial role in the regulation
of gene expression. Within the family of DNA methyltransferases (Dnmts), Dnmt3a and 3b …

DNA methylation patterns in genome are maintained during replication by a DNA
methyltransferase Dnmt1. Mouse Dnmt1 is a 180 kDa protein comprising the N-terminal …

While CpG methylation can be readily analyzed at the DNA sequence level in wild-type and
mutant cells, the actual DNA (cytosine-5) methyltransferases (DNMTs) responsible for in vivo …

The DNMT3-like protein, DNMT3L, is required for germ line DNA methylation, although it is
inactive as a DNA methyltransferase per se. Previous studies have shown that DNMT3L …