DNA methylation in the preimplantation embryo: the differing stories of the mouse and sheep

LE Young, N Beaujean - Animal reproduction science, 2004 - Elsevier
In mammals, active demethylation of cytosine methylation in the sperm genome prior to
forming a functional zygotic nucleus is thought to be a function of the oocyte cytoplasm …

Effect of limited DNA methylation reprogramming in the normal sheep embryo on somatic cell nuclear transfer

N Beaujean, J Taylor, J Gardner, I Wilmut… - Biology of …, 2004 - academic.oup.com
Active demethylation of cytosine residues in the sperm genome before forming a functional
zygotic nucleus is thought to be an important function of the oocyte cytoplasm for …

[PDF][PDF] Non-conservation of mammalian preimplantation methylation dynamics

N Beaujean, G Hartshorne, J Cavilla, J Taylor… - Current Biology, 2004 - cell.com
In mammals, active demethylation of sperm pronuclear DNA shortly after fertilisation is
thought to be important for reprogramming subsequent embryonic development [1–3]. A …

Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos

W Shi, F Dirim, E Wolf, V Zakhartchenko… - Biology of …, 2004 - academic.oup.com
Active demethylation of the paternal genome but not of the maternal genome occurs in
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …

Methylation dynamics in the early mammalian embryo: implications of genome reprogramming defects for development

T Haaf - DNA methylation: development, genetic disease and …, 2006 - Springer
In mouse and most other mammalian species, the paternal and maternal genomes undergo
parent-specific epigenetic reprogramming during preimplantation development. The …

Dynamics of DNA‐demethylation in early mouse and rat embryos developed in vivo and in vitro

I Zaitseva, S Zaitsev, N Alenina, M Bader… - Molecular …, 2007 - Wiley Online Library
Virtually all mammalian species including mouse, rat, pig, cow, and human, but not sheep
and rabbit, undergo genome‐wide epigenetic reprogramming by demethylation of the male …

[HTML][HTML] Dynamics of DNA methylation during early development of the preimplantation bovine embryo

KB Dobbs, M Rodriguez, MJ Sudano, MS Ortega… - PloS one, 2013 - journals.plos.org
There is species divergence in control of DNA methylation during preimplantation
development. The exact pattern of methylation in the bovine embryo has not been …

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

M Monk, M Boubelik, S Lehnert - Development, 1987 - journals.biologists.com
This paper shows stage-and tissue-specific global demethylation and remethylation
occurring during embryonic development. The egg genome is strikingly undermethylated …

Alteration of DNA demethylation dynamics by in vitro culture conditions in rabbit pre-implantation embryos

AR Reis e Silva, C Bruno, R Fleurot, N Daniel… - Epigenetics, 2012 - Taylor & Francis
Alterations to DNA methylation have been attributed to in vitro culture and may affect normal
embryo development. We chose to analyze DNA methylation reprogramming in the rabbit …

[HTML][HTML] De novo DNA methylation during monkey pre-implantation embryogenesis

F Gao, Y Niu, YE Sun, H Lu, Y Chen, S Li, Y Kang… - Cell research, 2017 - nature.com
Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes.
Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA …