Objective Neonatal seizures are the most frequent type of neurological emergency in
newborn infants, often being a consequence of prolonged perinatal asphyxia. Phenobarbital …

Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be
due to a developmental increase in expression of the neuronal Na+-K+-2 Cl− cotransporter …

Kaila, Löscher, and colleagues report that phenobarbital (PHB) and midazolam (MDZ)
attenuate neonatal seizures following birth asphyxia, but the former only when applied …

Objectives Bumetanide was suggested as an adjunct to phenobarbital for suppression of
neonatal seizures. This suggestion was based on the idea that bumetanide, by reducing …

Seizures in neonates, mainly caused by hypoxic-ischemic encephalopathy, are thought to
be harmful to the brain. Phenobarbital remains the first line drug therapy for the treatment of …

Neonatal seizures caused by perinatal asphyxia and hypoxic–ischemic encephalopathy can
be refractory to conventional anticonvulsants. This may be due to the depolarizing effects of …

In this response to a commentary by Ben‐Ari and Delpire on our recent study on the
pharmacology of neonatal seizures in a novel, physiologically validated rat model of birth …

Objective Birth asphyxia (BA) is the most frequent cause of neonatal death as well as central
nervous system (CNS) injury. BA is often associated with neonatal seizures, which only …

Current first-line drugs for the treatment of neonatal seizures have limited efficacy and are
associated with side effects. Uncontrolled seizures may exacerbate brain injury and …

Seizures after neonatal hypoxia are difficult to treat. A recent antiepileptic safety and dose-
finding study examined phenobarbital plus bumetanide, but was stopped owing to apparent …