The generation of gametes falls between two reprogramming phases. These phases are
characterised by profound periods of transcriptional activity, which define and reinforce …

DNA methylation is essential for the control of a number of biological mechanisms in
mammals [1]. Mammalian development is accompanied by two major waves of genome …

Abstract Development from separate parental germ cells through fertilization and
proceeding to a fully functioning adult animal occurs through an intricate program of …

In mammalian development, epigenetic modifications, including DNA methylation patterns,
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …

Epigenetics refers to non-sequence based mechanisms that control gene expression and
has been described as the next 'frontier'in genetics. This chapter focuses on DNA …

DNA methylation and demethylation are crucial for modulating gene expression and
regulating cell differentiation. Functions and mechanisms of DNA methylation/demethylation …

DNA methylation is involved in a number of important processes such as maintaining
genome stability, silencing of retrotransposons, co-ordinating mono-alleleic expression of …

The regulation of the genome relies on the epigenome to instruct, define and restrict the
activities of growth and development. Among the cohort of epigenetic instructions, DNA …

The epigenetic modification of DNA by methylation at cytosine residues is initiated in the
germ line and is required for normal embryonic development in mammals. Marked …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …