DNA methylation is an epigenetic modification involved in both normal developmental
processes and disease states through the modulation of gene expression and the …

Background DNA methylation has been linked to genome regulation and dysregulation in
health and disease respectively, and methods for characterizing genomic DNA methylation …

DNA methylation primarily occurs at CpG dinucleotides in mammals and is a common
epigenetic mark that plays a critical role in the regulation of gene expression. Profiling DNA …

Cytosine methylation is the most common covalent modification of DNA in eukaryotes. DNA
methylation has an important role in many aspects of biology, including development and …

DNA methylation plays a key role in regulating eukaryotic gene expression. Although
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …

One of the most challenging projects in the field of epigenetics is the generation of detailed
functional maps of DNA methylation in different cell and tissue types in normal and disease …

DNA methylation plays a critical role in the regulation of gene expression. The ability to
access the methylation status for a large number of genes or the entire genome should …

DNA methylation is an epigenetic modification that plays an important role in regulating
gene expression and therefore a broad range of biological processes and diseases. DNA …

There are numerous approaches to decipher a whole genome DNA methylation profile
(“methylome”), each varying in cost, throughput and resolution. The gold standard of these …

DNA methylation stabilizes developmentally programmed gene expression states. Aberrant
methylation is associated with disease progression and is a common feature of cancer …