Differentially methylated DNA regions in early childhood wheezing: An epigenome‐wide study using saliva

M Popovic, V Fiano, F Fasanelli… - Pediatric Allergy and …, 2019 - Wiley Online Library
Background Epigenetics may play a role in wheezing and asthma development. We aimed
to examine infant saliva DNA methylation in association with early childhood wheezing …

Global hypomethylation in childhood asthma identified by genome‐wide DNA‐methylation sequencing preferentially affects enhancer regions

L Thürmann, M Klös, SD Mackowiak, M Bieg, T Bauer… - Allergy, 2023 - Wiley Online Library
Background Childhood asthma is a result of a complex interaction of genetic and
environmental components causing epigenetic and immune dysregulation, airway …

DNA methylation in childhood asthma: an epigenome-wide meta-analysis

CJ Xu, C Söderhäll, M Bustamante, N Baïz… - The lancet Respiratory …, 2018 - thelancet.com
Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …

[HTML][HTML] Epigenome-wide meta-analysis of DNA methylation and childhood asthma

SE Reese, CJ Xu, HT Den Dekker, MK Lee… - Journal of Allergy and …, 2019 - Elsevier
Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …

DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study

E Forno, T Wang, C Qi, Q Yan, CJ Xu… - The lancet Respiratory …, 2019 - thelancet.com
Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …

DNA methylation and childhood asthma in the inner city

IV Yang, BS Pedersen, A Liu, GT O'Connor… - Journal of Allergy and …, 2015 - Elsevier
Background Epigenetic marks are heritable, influenced by the environment, direct the
maturation of T lymphocytes, and in mice enhance the development of allergic airway …

Nasal DNA methylation profiling of asthma and rhinitis

C Qi, Y Jiang, IV Yang, E Forno, T Wang… - Journal of allergy and …, 2020 - Elsevier
Background Epigenetic signatures in the nasal epithelium, which is a primary interface with
the environment and an accessible proxy for the bronchial epithelium, might provide insights …

The nasal methylome and childhood atopic asthma

IV Yang, BS Pedersen, AH Liu, GT O'Connor… - Journal of Allergy and …, 2017 - Elsevier
Background Given the strong environmental influence on both epigenetic marks and allergic
asthma in children, the epigenetic alterations in respiratory epithelia might provide insight …

[HTML][HTML] Shared DNA methylation signatures in childhood allergy: the MeDALL study

CJ Xu, O Gruzieva, C Qi, A Esplugues… - Journal of allergy and …, 2021 - Elsevier
Background Differential DNA methylation associated with allergy might provide novel
insights into the shared or unique etiology of asthma, rhinitis, and eczema. Objective We …

Newborn DNA methylation and asthma acquisition across adolescence and early adulthood

L Li, JW Holloway, S Ewart, SH Arshad… - Clinical & …, 2022 - Wiley Online Library
Background Little is known about the association of newborn DNA methylation (DNAm) with
asthma acquisition across adolescence and early adult life. Objective We aim to identify …