The pineal neurohormone melatonin (MLT) has been widely shown to exert an
immunostimulatory and antiapoptotic role, mainly by acting on Th cells and on T and B cell …

The pineal hormone melatonin (MLT) exerts a variety of effects on the immune system. MLT
activates immune cells and enhances inflammatory cytokine and nitric oxide production …

The pineal neurohormone melatonin is widely recognized as exerting important
immunoenhancing effects that act on specific receptors in immunocompetent cells. This …

Our perception of the function of the pineal gland and its hormone melatonin has attained a
new dimension during the last decade. Through melatonin, the pineal becomes a principal …

We have previously shown that constant darkness enhances autoimmunity to type II
collagen (CII) and exaggerates development of collagen-induced arthritis (CIA) in DBA/1 …

Melatonin is not only synthesized by the pineal gland but also in many other organs and
tissues of the body, particularly by lymphoid organs such as the bone marrow, thymus and …

To extend our previous findings that exposure to constant darkness (stimulation of
endogenous melatonin release) as well as treatment with exogenous melatonin magnifies …

Rheumatoid arthritis (RA), the most prevalent autoimmune arthritis worldwide, usually
presents with a circannual manner and, meanwhile, follows a circadian rhythm for symptoms …

Asubstance from pineal gland extracts, which lightens the skin melanocytes of amphibians
and fishes, was isolated in 1958 and called melatonin (MLT, N-acetyl-5-methoxytryptamine) …

Rheumatoid arthritis (RA) is an inflammatory joint disorder characterized by synovial
proliferation and inflammation, with eventual joint destruction if inadequately treated …