Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO),
and despite decades of research, novel initiatives are drastically needed. According to the …

Sepsis is a major cause of mortality in critically ill patients and develops as a result of the
host response to infection. In recent years, important advances have been made in …

Sepsis is a massive inflammatory response mediated by infection, characterized by
oxidative stress, release of cytokines, and mitochondrial dysfunction. Melatonin accumulates …

Melatonin is a versatile molecule, synthesized not only in the pineal gland, but also in many
other organs. Melatonin plays an important physiologic role in sleep and circadian rhythm …

Melatonin, also known as N‐acetyl‐5‐methoxytryptamine, is a ubiquitously acting molecule
that is produced by the pineal gland and other organs of animals, including humans. As …

Melatonin is a versatile molecule, synthesized not only by the pineal gland, but also in small
amounts by many other organs like retina, gastrointestinal tract, thymus, bone marrow …

Purpose Melatonin used as an exogenous drug has been documented to have potent
antioxidant and anti-inflammatory effects in animal model. We aimed to examine the effect of …

Objectives: Melatonin has been demonstrated to improve survival after experimental sepsis
via antioxidant effects. Yet, recent evidence suggests that this protective capacity may also …

Objective Melatonin is involved in the regulation of the sleep-wake cycle and exhibits
multiple interactions with the neuroendocrine and the immune system. Melatonin secretion …

Critical illness and particularly sepsis are associated with a significant redox imbalance
resulting from an increased production of oxidant species and a decrease in endogenous …