Abstract Background C3 glomerulopathy (C3G) is a rare, but severe glomerular disease with
grim prognosis. The complex pathogenesis is just unfolding, and involves acquired as well …

Results Evidence of AP activation was demonstrable in all cases and included increased
levels of soluble membrane attack complex (all cases), positive AP functional assays (four …

Postinfectious glomerulonephritis is a common disorder that develops following an infection.
In the majority of cases, there is complete recovery of renal function within a few days to …

Abstract In C3 glomerulopathy (C3G), the alternative pathway of complement is frequently
overactivated by autoantibodies that stabilize the C3 convertase C3bBb. Anti-C3b and anti …

C3 glomerulopathy describes a spectrum of disorders with glomerular pathology associated
with C3 cleavage product deposition and with defective complement action and regulation …

Until recently, membranoproliferative glomerulonephritis (MPGN) was clinically classified as
either primary, idiopathic MPGN or as secondary MPGN when an underlying aetiology was …

C3 glomerulopathy refers to those renal lesions characterized histologically by predominant
C3 accumulation within the glomerulus, and pathogenetically by aberrant regulation of the …

Results Eighty patients with C3 glomerulopathy were identified: 21 with DDD and 59 with
C3GN. Patients with DDD were younger, more likely to have low serum C3 levels, and more …

Dense deposit disease and glomerulonephritis with isolated C3 deposits are
glomerulopathies characterized by deposits of C3 within or along the glomerular basement …

C3 Glomerulopathies, which include Dense Deposit Disease and C3 Glomerulonephritis,
are associated with genetic and acquired dysregulation of the C3 convertase alternative …