Isoform switch of TET1 regulates DNA demethylation and mouse development
The methylcytosine oxidase TET proteins play important roles in DNA demethylation and
development. However, it remains elusive how exactly they target substrates and execute …
development. However, it remains elusive how exactly they target substrates and execute …
A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer
TET1 oxidizes methylated cytosine into 5-hydroxymethylcytosine (5hmC), resulting in
regulation of DNA methylation and gene expression. Full length TET1 (TET1FL) has a CXXC …
regulation of DNA methylation and gene expression. Full length TET1 (TET1FL) has a CXXC …
TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells
TET1 is a 5-methylcytosine dioxygenase and its DNA demethylating activity has been
implicated in pluripotency and reprogramming. However, the precise role of TET1 in DNA …
implicated in pluripotency and reprogramming. However, the precise role of TET1 in DNA …
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
Ten-eleven translocation 1–3 (Tet1–3) proteins have recently been discovered in
mammalian cells to be members of a family of DNA hydroxylases that possess enzymatic …
mammalian cells to be members of a family of DNA hydroxylases that possess enzymatic …
The DNA dioxygenase Tet1 regulates H3K27 modification and embryonic stem cell biology independent of its catalytic activity
Abstract Tet enzymes (Tet1/2/3) oxidize 5-methylcytosine to promote DNA demethylation
and partner with chromatin modifiers to regulate gene expression. Tet1 is highly expressed …
and partner with chromatin modifiers to regulate gene expression. Tet1 is highly expressed …
Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond
Cytosine methylation is the major epigenetic modification of metazoan DNA. Although there
is strong evidence that active DNA demethylation occurs in animal cells, the molecular …
is strong evidence that active DNA demethylation occurs in animal cells, the molecular …
TET enzymes, DNA demethylation and pluripotency
SE Ross, O Bogdanovic - Biochemical Society Transactions, 2019 - portlandpress.com
Ten-eleven translocation (TET) methylcytosine dioxygenases (TET1, TET2, TET3) actively
cause demethylation of 5-methylcytosine (5mC) and produce and safeguard …
cause demethylation of 5-methylcytosine (5mC) and produce and safeguard …
Tet enzymes, variants, and differential effects on function
P Melamed, Y Yosefzon, C David… - Frontiers in cell and …, 2018 - frontiersin.org
Discovery of the ten-eleven translocation 1 (TET) methylcytosine dioxygenase family of
enzymes, nearly 10 years ago, heralded a major breakthrough in understanding the …
enzymes, nearly 10 years ago, heralded a major breakthrough in understanding the …
5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation
In mammals, cytosine methylation (5mC) is widely distributed throughout the genome but is
notably depleted from active promoters and enhancers. While the role of DNA methylation in …
notably depleted from active promoters and enhancers. While the role of DNA methylation in …
Tet1 and Tet2 protect DNA methylation canyons against hypermethylation
L Wiehle, G Raddatz, T Musch… - … and cellular biology, 2016 - Taylor & Francis
DNA methylation is a dynamic epigenetic modification with an important role in cell fate
specification and reprogramming. The Ten eleven translocation (Tet) family of enzymes …
specification and reprogramming. The Ten eleven translocation (Tet) family of enzymes …