We describe the construction, evaluation and application of cDNA libraries from unfertilized
oocytes, and single 2-cell, 4-cell, 7-cell and blastocyst stage embryos. The corresponding …

Methylation ofcytosine residues in mammalian genomes is associated with transcriptional
repression and inactive chromatin. It has been shown that methylation of DNA is essential …

CpG islands are short stretches of DNA containing a high density of non–methylated CpG
dinucleotides, predominantly associated with coding regions. We have constructed an …

The 5'region of the gene encoding human X chromosome-linked phosphoglycerate kinase 1
(PGK1) is a promoter-containing CpG island known to be methylated at 119 of 121 CpG …

The human genome contains∼ 30,000 CpG islands (CGIs). While CGIs associated with
promoters nearly always remain unmethylated, many of the∼ 9,000 CGIs lying within gene …

CpG methylation, the most common epigenetic modification of vertebrate genomes, is
primarily associated with transcriptional repression. MeCP2, MBD1, MBD2, MBD3 and …

A correlation between DNA methylation and transcriptional silencing has existed for many
years. Recently, substantial progress has been reported in the search for proteins that …

A systematic search for expressed sequences in the human Xq28 region resulted in the
isolation of 8.5 kb large contigs of human and murine cDNAs with no apparent conserved …

Vertebrate genomes are heavily methylated at cytosines in the sequence CpG. The
biological role of this modification is probably mediated by DMA binding proteins that are …

CpG-binding protein is a transcriptional activator that exhibits a unique DNA binding
specificity for unmethylated CpG motifs. CpG-binding protein contains a cysteine-rich CXXC …