Posttranslational modification with small ubiquitin-like modifier (Sumo) regulates numerous
cellular and developmental processes. Sumoylation is dynamic with deconjugation by Sumo …

Protein sumoylation has emerged as an important regulatory mechanism for the
transcriptional machinery. Sumoylation is a highly dynamic process that is regulated in …

Signaling by the ubiquitin-related SUMO pathway relies on coordinated conjugation and
deconjugation events. SUMO-specific deconjugating enzymes counterbalance …

Post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining
feature of eukaryotic cells. Sumoylation has crucial roles in the regulatory challenges that …

The modification of proteins by small ubiquitin‐like modifier (SUMO) is crucial for the
regulation of diverse cellular processes. Protein SUMOylation is reversed by isopeptidases …

SUMOylation is an essential modification that regulates hundreds of proteins in eukaryotic
cells. Owing to its dynamic nature and low steady-state levels, endogenous SUMOylation is …

SUMO protease SENP1 is elevated in multiple carcinomas including prostate cancer (PCa).
SENP1 exhibits carcinogenic properties; it promotes androgen receptor-dependent and …

The covalent modification of proteins by the small ubiquitin-like protein SUMO has been
implicated in the regulation of numerous biological processes, including nucleocytoplasmic …

The covalent attachment of SUMO (small ubiquitin-like protein modifier) to target proteins
results in modifications in their activity, binding interactions, localization or half-life. The …

Reversible modification of proteins by SUMO (small ubiquitin-like modifier) affects a large
number of cellular processes. In striking contrast to the related ubiquitin pathway, only a few …