Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now
established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds …

Modification of cellular proteins by the ubiquitin-like protein SUMO is essential for nuclear
metabolism and cell cycle progression in yeast. X-ray structures of the human Senp2 …

Posttranslational modification with small ubiquitin-like modifiers (SUMOs) alters the function
of proteins involved in diverse cellular processes. SUMO-specific enzymes conjugate …

SUMOs are small ubiquitin-related polypeptides that are reversibly conjugated to many
nuclear proteins. Although the number of identified substrates has grown rapidly, relatively …

Conjugation of the small ubiquitin-like modifier (SUMO) to target proteins regulates
numerous biological processes and has been implicated in tumorigenesis and metastasis …

Sumoylation is a posttranslational modification implicated in a variety of cellular activities,
and its role in a number of human pathogeneses such as cleft lip/palate has been well …

Post-translational modification with the ubiquitin-like SUMO protein is involved in the
regulation of many cellular key processes. The SUMO system modulates signal transduction …

SENPs are proteases that participate in the regulation of SUMOylation by generating mature
small ubiquitin-related modifiers (SUMO) for protein conjugation (endopeptidase activity) …

One of the more rapidly expanding fields in cell signalling nowadays is the characterization
of proteins conjugated to Ub (ubiquitin) or Ub-like peptides, such as SUMO (small Ub …