The post-translational modification SUMOylation is a major regulator of protein function that
plays an important role in a wide range of cellular processes. SUMOylation involves the …

Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-
translational modification. However, a potent and selective inhibitor targeting the SUMO …

The SPOP gene, which encodes an E3 ubiquitin ligase adaptor, is frequently mutated in a
number of cancer types. However, the mechanisms by which SPOP functions as a tumor …

Two Sentrin/small ubiquitin-like modifier (SUMO)-specific protease 7 (SENP7) variants are
naturally expressed in breast epithelia. Breast cancer (BCa) onset down-regulates the short …

SUMO/sentrin specific protease 1 (Senp1) is an important regulation protease in the protein
sumoylation, which affects the cell cycle, proliferation and differentiation. The role of Senp1 …

The SUMO protease SENP6 maintains genomic stability, but mechanistic understanding of
this process remains limited. We find that SENP6 deconjugates SUMO2/3 polymers on a …

SUMOylation (small ubiquitin-like modifier) in the DNA double-strand break (DSB) response
regulates recruitment, activity, and clearance of repair factors. However, our understanding …

The ubiquitin-like SUMO system regulates gene expression, but the molecular insights into
this process are incomplete. We show that the SUMO-specific isopeptidase SENP3 controls …

BACKGROUND Overexpression of NUSAP1 is associated with poor prognosis in prostate
cancer, but little is known about what leads to its overexpression. Based on previous …

African-American (AA) men experience an increased risk of developing prostate cancers as
well as increased mortality following treatment as compared to European-American (EA) …