Melatonin: Protection against age-related cardiac pathology

G Favero, L Franceschetti, B Buffoli… - Ageing research …, 2017 - Elsevier
Aging is a complex and progressive process that involves physiological and metabolic
deterioration in every organ and system. Cardiovascular diseases are one of the most …

Emerging roles of melatonin in mitigating abiotic and biotic stresses of horticultural crops

RK Tiwari, MK Lal, KC Naga, R Kumar… - Scientia …, 2020 - Elsevier
Environmental stress and pathogen infection are the major limiting factors in worldwide
horticulture production, resulting in huge yield loss. Melatonin (N-acetyl-5 …

Melatonin as an antioxidant: under promises but over delivers

RJ Reiter, JC Mayo, DX Tan, RM Sainz… - Journal of pineal …, 2016 - Wiley Online Library
Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …

Effect of exogenous melatonin in fruit postharvest, crosstalk with hormones, and defense mechanism for oxidative stress management

H Sati, A Khandelwal, S Pareek - Food Frontiers, 2023 - Wiley Online Library
Derived from tryptophan, melatonin (MT; N‐acetyl‐5‐methoxytryptamine) is a ubiquitous
indoleamine that is widely distributed in species ranging from microorganisms to mammals …

New insights into the role of melatonin in plants and animals

E Agathokleous, M Kitao, EJ Calabrese - Chemico-biological interactions, 2019 - Elsevier
Melatonin is a hormone produced in animals by the pineal gland and in plants under stress.
Melatonin research has expanded rapidly, affecting an impressive enhancement in the …

Melatonin as a potent and inducible endogenous antioxidant: synthesis and metabolism

DX Tan, LC Manchester, E Esteban-Zubero, Z Zhou… - Molecules, 2015 - mdpi.com
Melatonin is a tryptophan-derived molecule with pleiotropic activities. It is present in almost
all or all organisms. Its synthetic pathway depends on the species in which it is measured …

Melatonin: pharmacology, functions and therapeutic benefits

S Tordjman, S Chokron, R Delorme… - Current …, 2017 - ingentaconnect.com
Background: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal
gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of …

Melatonin: a neurotrophic factor?

A Miranda-Riestra, R Estrada-Reyes… - Molecules, 2022 - mdpi.com
Melatonin, N-acetyl-5-hydroxytryptamine, is a hormone that synchronizes the internal
environment with the photoperiod. It is synthesized in the pineal gland and greatly depends …

Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance

A Carrillo‐Vico, JR Calvo, P Abreu… - The FASEB …, 2004 - Wiley Online Library
It has been historically assumed that the pineal gland is the major source of melatonin (N‐
acetyl‐5‐methoxytryptamine) in vertebrates. Melatonin plays a central role in fine‐tuning …

[PDF][PDF] Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.

R Reiter, D Tan, J Mayo, R Sainz… - Acta Biochimica …, 2003 - frontierspartnerships.org
This brief resume enumerates the multiple actions of melatonin as an antioxidant. This
indoleamine is produced in the vertebrate pineal gland, the retina and possibly some other …