Growing knowledge on the pathophysiology of human intracranial aneurysms (IAs) has led
to a deeper understanding of the processes of IA growth and rupture. In past decades …

The pathogenesis and natural history of intracranial aneurysm (IA) remains poorly
understood. To this end, animal models with induced cerebral vessel lesions mimicking …

Cerebral aneurysm rupture is a devastating event resulting in subarachnoid hemorrhage
and is associated with significant morbidity and death. Up to 50% of individuals do not …

OBJECTIVE Unruptured intracranial aneurysms (UIAs) are relatively common lesions that
may cause devastating intracranial hemorrhage, thus producing considerable suffering and …

Intracranial aneurysms (IA) are characterized by weakened cerebral vessel walls that may
lead to rupture and subarachnoid hemorrhage. The mechanisms behind their formation and …

Intracranial aneurysms (IAs) are rare vascular lesions that are more frequently found in
women. The pathophysiology behind the formation and growth of IAs is complex. Hence, to …

Aneurysmal subarachnoid hemorrhage is a major cause of morbidity and mortality, with
aneurysms affecting 1% of the population and causing 30,000 annual cases of rupture in the …

Intracranial aneurysm (IA) animal models are paramount to study IA pathophysiology and to
test new endovascular treatments. A number of in vivo imaging modalities are available to …

An intracranial aneurysm (IA) is a pathological state of a cerebral artery in which the elastin
and smooth muscle cells found in the healthy arterial wall are absent. Rupture of an IA is a …

Animal models make an important contribution to our basic understanding of the
pathobiology of human brain aneurysms, are indispensable in testing novel treatment …