Effect of limited DNA methylation reprogramming in the normal sheep embryo on somatic cell nuclear transfer
N Beaujean, J Taylor, J Gardner, I Wilmut… - Biology of …, 2004 - academic.oup.com
Active demethylation of cytosine residues in the sperm genome before forming a functional
zygotic nucleus is thought to be an important function of the oocyte cytoplasm for …
zygotic nucleus is thought to be an important function of the oocyte cytoplasm for …
DNA methylation in the preimplantation embryo: the differing stories of the mouse and sheep
LE Young, N Beaujean - Animal reproduction science, 2004 - Elsevier
In mammals, active demethylation of cytosine methylation in the sperm genome prior to
forming a functional zygotic nucleus is thought to be a function of the oocyte cytoplasm …
forming a functional zygotic nucleus is thought to be a function of the oocyte cytoplasm …
Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos
W Shi, F Dirim, E Wolf, V Zakhartchenko… - Biology of …, 2004 - academic.oup.com
Active demethylation of the paternal genome but not of the maternal genome occurs in
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …
Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos
F Santos, V Zakhartchenko, M Stojkovic, A Peters… - Current Biology, 2003 - cell.com
During differentiation, somatic nuclei acquire highly specialized DNA and chromatin
modifications, which are thought to result in cellular memory of the differentiated state [1] …
modifications, which are thought to result in cellular memory of the differentiated state [1] …
DNA methylation patterns in tissues from mid-gestation bovine foetuses produced by somatic cell nuclear transfer show subtle abnormalities in nuclear …
C Couldrey, RSF Lee - BMC developmental biology, 2010 - Springer
Background Cloning of cattle by somatic cell nuclear transfer (SCNT) is associated with a
high incidence of pregnancy failure characterized by abnormal placental and foetal …
high incidence of pregnancy failure characterized by abnormal placental and foetal …
[HTML][HTML] Limited demethylation leaves mosaic‐type methylation states in cloned bovine pre‐implantation embryos
YK Kang, JS Park, DB Koo, YH Choi, SU Kim… - The EMBO …, 2002 - embopress.org
Cloning by nuclear transfer (NT) has been riddled with difficulties: most clones die before
birth and survivors frequently display growth abnormalities. The cross‐species similarity in …
birth and survivors frequently display growth abnormalities. The cross‐species similarity in …
Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos
D Bourc'his, D Le Bourhis, D Patin, A Niveleau… - Current Biology, 2001 - cell.com
Full-term development has now been achieved in several mammalian species by transfer of
somatic nuclei into enucleated oocytes [1, 2]. Although a high proportion of such …
somatic nuclei into enucleated oocytes [1, 2]. Although a high proportion of such …
Nuclear reprogramming of cloned embryos produced in vitro
YM Han, YK Kang, DB Koo, KK Lee - Theriogenology, 2003 - Elsevier
Despite the fact that cloned animals derived from somatic cells have been successfully
generated in a variety of mammalian species, there are still many unsolved problems with …
generated in a variety of mammalian species, there are still many unsolved problems with …
DNA methylation in porcine preimplantation embryos developed in vivo and produced by in vitro fertilization, parthenogenetic activation and somatic cell nuclear …
DNA demethylation and remethylation are crucial for reprogramming of the differentiated
parental/somatic genome in the recipient ooplasm upon somatic cell nuclear transfer. Here …
parental/somatic genome in the recipient ooplasm upon somatic cell nuclear transfer. Here …
Epigenetic alteration of the donor cells does not recapitulate the reprogramming of DNA methylation in cloned embryos
G Wee, JJ Shim, DB Koo, JI Chae, KK Lee… - …, 2007 - rep.bioscientifica.com
Epigenetic reprogramming is a prerequisite process during mammalian development that is
aberrant in cloned embryos. However, mechanisms that evolve abnormal epigenetic …
aberrant in cloned embryos. However, mechanisms that evolve abnormal epigenetic …
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