Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy

LP Gunawardhana, KJ Baines, J Mattes… - Pediatric …, 2014 - Wiley Online Library
Background Asthma is a complex disease that involves both genetic factors and
environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may …

DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma

KM Magnaye, SM Clay… - Proceedings of the …, 2022 - National Acad Sciences
Maternal asthma (MA) is among the most consistent risk factors for asthma in children.
Possible mechanisms for this observation are epigenetic modifications in utero that have …

[HTML][HTML] Epigenome-wide meta-analysis of DNA methylation and childhood asthma

SE Reese, CJ Xu, HT Den Dekker, MK Lee… - Journal of Allergy and …, 2019 - Elsevier
Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …

Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation

CV Breton, KD Siegmund, BR Joubert, X Wang, W Qui… - PloS one, 2014 - journals.plos.org
Background Smoking while pregnant is associated with a myriad of negative health
outcomes in the child. Some of the detrimental effects may be due to epigenetic …

DNA methylation in childhood asthma: an epigenome-wide meta-analysis

CJ Xu, C Söderhäll, M Bustamante, N Baïz… - The lancet Respiratory …, 2018 - thelancet.com
Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …

DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study

E Forno, T Wang, C Qi, Q Yan, CJ Xu… - The lancet Respiratory …, 2019 - thelancet.com
Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …

Differentially methylated DNA regions in early childhood wheezing: An epigenome‐wide study using saliva

M Popovic, V Fiano, F Fasanelli… - Pediatric Allergy and …, 2019 - Wiley Online Library
Background Epigenetics may play a role in wheezing and asthma development. We aimed
to examine infant saliva DNA methylation in association with early childhood wheezing …

Nasal DNA methylation is associated with childhood asthma

X Zhang, JM Biagini Myers, JD Burleson, A Ulm… - …, 2018 - Taylor & Francis
Aim: We aim to study DNA methylation (DNAm) variations associated with childhood
asthma. Methods: Nasal DNAm was compared between sibling pairs discordant for asthma …

Sex‐specific associations of asthma acquisition with changes in DNA methylation during adolescence

R Patel, F Solatikia, H Zhang, A Wolde… - Clinical & …, 2021 - Wiley Online Library
Background Underlying biological mechanisms involved in sex differences in asthma status
changes from pre‐to post‐adolescence are unclear. DNA methylation (DNAm) has been …

In utero tobacco smoke exposure, DNA methylation, and asthma in Latino children

AM Neophytou, SS Oh, D Hu, S Huntsman… - Environmental …, 2019 - journals.lww.com
Background: Maternal smoking during pregnancy is a risk factor for chronic disease later in
life and has been associated with variability of DNA methylation at specific cytosine …