Dementia is a complex clinical condition characterized by several cognitive impairments that
interfere with patient independence in executing everyday tasks. Various neurodegenerative …

Alzheimer's disease (AD) is a large and growing public health problem. It is characterized by
the accumulation of amyloid-β peptides and abnormally phosphorylated tau proteins that are …

Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …

Sex is an important factor that contributes to the clinical and biological heterogeneities in
Alzheimer's disease (AD), but the regulatory mechanisms underlying sex disparity in AD are …

Alzheimer's disease (AD) is the most widespread neurodegenerative disorder and has
caused a major global health concern with the aging of the population. Recent studies have …

Epigenetic dysregulation of gene expression is thought to be critically involved in the
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation …

Epigenetics is believed to play a role in Alzheimer's disease (AD). DNA methylation, the
most investigated epigenetic hallmark, is a reversible mechanism that modifies genome …

Importance Recent large-scale genome-wide association studies have discovered several
genetic variants associated with Alzheimer disease (AD); however, the extent to which DNA …

Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …

Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of
various neurodegenerative diseases. In this review, we discuss advances that have been …