Alterations in global DNA methylation and hydroxymethylation are not detected in A lzheimer's disease
Aims Genetic factors do not seem to account fully for A lzheimer disease (AD) pathogenesis.
There is evidence for the contribution of environmental factors, whose effect may be …
There is evidence for the contribution of environmental factors, whose effect may be …
The epigenetic dimension of Alzheimer's disease: causal, consequence, or curiosity?
MJ Millan - Dialogues in clinical neuroscience, 2014 - Taylor & Francis
Early-onset, familial Alzheimer's disease (AD) is rare and may be attributed to disease-
causinq mutations. By contrast, late onset, sporadic (non-Mendelian) AD is far more …
causinq mutations. By contrast, late onset, sporadic (non-Mendelian) AD is far more …
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
We used a collection of 708 prospectively collected autopsied brains to assess the
methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that …
methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that …
Epigenetic changes in the progression of Alzheimer's disease
MA Bradley-Whitman, MA Lovell - Mechanisms of ageing and development, 2013 - Elsevier
Abstract The formation of 5-hydroxymethylcytosine (5hmC), a key intermediate of DNA
demethylation, is driven by the ten eleven translocation (TET) family of proteins that oxidize …
demethylation, is driven by the ten eleven translocation (TET) family of proteins that oxidize …
Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease
The pathogenesis of Alzheimer's disease (AD) and the commonest cause of dementia in the
elderly remain incompletely understood. Recently, epigenetic modifications have been …
elderly remain incompletely understood. Recently, epigenetic modifications have been …
Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
Background People with neurodegenerative disorders show diverse clinical syndromes,
genetic heterogeneity, and distinct brain pathological changes, but studies report overlap …
genetic heterogeneity, and distinct brain pathological changes, but studies report overlap …
Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease
L Shu, W Sun, L Li, Z Xu, L Lin, P Xie, H Shen, L Huang… - BMC genomics, 2016 - Springer
Background Alzheimer's disease (AD) is the most common form of neurodegenerative
disorder that leads to a decline in cognitive function. In AD, aggregates of amyloid β peptide …
disorder that leads to a decline in cognitive function. In AD, aggregates of amyloid β peptide …
Genome-wide correlation of DNA methylation and gene expression in postmortem brain tissues of opioid use disorder patients
Background Opioid use disorder (OUD) affects millions of people, causing nearly 50 000
deaths annually in the United States. While opioid exposure and OUD are known to cause …
deaths annually in the United States. While opioid exposure and OUD are known to cause …
Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception
Background The well-established association of chronological age with changes in DNA
methylation is primarily founded on the analysis of large sets of blood samples, while …
methylation is primarily founded on the analysis of large sets of blood samples, while …
Aging effects on DNA methylation modules in human brain and blood tissue
Background Several recent studies reported aging effects on DNA methylation levels of
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …