Melatonin is a small, highly conserved indole with numerous receptor-mediated and
receptor-independent actions. Receptor-dependent functions include circadian rhythm …

Melatonin's pleiotropic actions begin from controlling day/night cycle and
hypothalamic/pituitary axes to, for example, vasomotor effects, immunomodulation, antilipid …

Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity
occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including …

Melatonin is a ubiquitous natural neurotransmitter-like compound produced primarily by the
pineal gland. This agent is involved in numerous aspects of the biological and physiologic …

This review summarizes the metabolism, secretion, regulation and sites of action of
melatonin. An updated description of the melatonin receptors, including their signal …

The functional versatility and diversity of melatonin has exceeded everyone's expectations.
The evidence is substantial that melatonin has multiple receptor-mediated and receptor …

The fact that the full extent of the function of the pineal gland has not yet been elucidated,
has stimulated melatonin research worldwide. This review introduces melatonin's …

Melatonin, an endogenous signal of darkness, is an important component of the body's
internal time-keeping system. As such it regulates major physiological processes including …

Highlights•Pathways controlling melatonin secretion are complex.•There are various causes
of melatonin disturbance.•Evaluation of melatonin secretion clinically requires long time …

Melatonin is a fascinating molecule that has captured the imagination of many scientists
since its discovery in 1958. In recent times, the focus has changed from investigating its …