The pineal hormone melatonin exhibits remarkable functional versatility. Shortly after its
discovery, melatonin was functionally linked to the regulation of the neuroendocrine axis …

Introduction 3. Melatonin receptors 3.1. MT1 and MT2 melatonin receptors 3.1. 1. Molecular
structure 3.1. 2. Pharmacology 3.1. 2.1. Efficacy, potency and affinity 3.1. 2.2. Ligand …

Melatonin is an uncommonly widely distributed molecule. It is found throughout the plant
and animal kingdoms, ie, perhaps in every living organism. Within vertebrate organisms …

Neurodegenerative diseases are the second most common cause of death and
characterized by progressive impairments in movement or mental functioning in the central …

Melatonin, widely used to counter transatlantic travel jet lag and insomnia, is synthesized in
the suprachiasmatic nucleus of the anterior pituitary gland. Its release into the circulation is …

Melatonin is a tryptophan-derived molecule with pleiotropic activities. It is present in almost
all or all organisms. Its synthetic pathway depends on the species in which it is measured …

Melatonin is a small natural compound, so called a neuro‐hormone that is synthesized
mainly in pineal gland in animals. Its main role is to master the clock of the body, under the …

The high incidence of age-related diseases in the increasing population of elderly people
has stimulated interest in the search for protective agents that have the capability of …

There is growing evidence demonstrating the complexity of melatonin's role in modulating a
diverse number of physiological processes. This complexity could be attributed to the fact …

Endogenous melatonin is synthesized from tryptophan via 5-hydroxytryptamine. It is
considered an indoleamine from a biochemical point of view because the melatonin …