Our previously published data link P-selectin-reactive chondroitin sulfate structures on the
surface of breast cancer cells to metastatic behavior of cells. We have shown that a …

Introduction: We have previously shown that the expression of carbohydrate (chondroitin 4)
sulfotransferase-11 (CHST11) is elevated in human breast cancer tissues, and that its …

CST6 is a breast tumor suppressor gene that is expressed in normal breast epithelium, but is
epigenetically silenced as a consequence of promoter hypermethylation in metastatic breast …

Introduction We have previously demonstrated that chondroitin sulfate glycosaminoglycans
(CS-GAGs) on breast cancer cells function as P-selectin ligands. This study was performed …

Heparan sulfate 3‐O‐sulfotransferase 2 (HS3ST2), an enzyme mediating 3‐O‐sulfation of
heparan sulfate (HS), is silenced by hypermethylation in breast cancer. As HS has an …

Ovarian cancer (OvCa) accounts for the highest tumor-related mortality among
gynecological malignancies, but the underlying mechanisms are poorly understood …

Cystatin M (CST6) is a candidate breast cancer tumor suppressor that is expressed in
normal and premalignant breast epithelium, but not in metastatic breast cancer cell lines …

OBJECTIVES: We have recently shown that detection of CST6 promoter methylation in
primary breast tumors can provide important prognostic information in patients with operable …

Breast cancer is the leading cause of cancer-related deaths in women worldwide. Several
studies have indicated that abnormal chondroitin sulfate (CS) chains accumulate in breast …

The methylation status of cystatin M (CST6) gene in breast tumors was investigated and its
prognostic significance as a novel breast cancer biomarker was evaluated. Using …