There is now considerable evidence suggesting that alterations in the DNA methylating
machinery play an important role in tumorigenesis and tumour progression. For example …

Changes in the DNA methylation profile, including general genomic hypomethylation and
regional hypermethylation, have been shown to coexist in many neoplastic tissues …

Aberrant methylation of 5′ CpG islands is a key epigenetic event in many human cancers.
A PCR-based technique of methylated CpG island amplification followed by …

Deregulated methylation of cytosine in DNA is a frequent finding in malignancy that is
reflected by general genomic hypomethylation and regional hypermethylation that includes …

Methylation dysregulation has been a consistent finding in various malignancies, particularly
those where the pathogenetic mechanisms are unclear. In order to test the hypothesis that …

The mechanisms underlying the de novo methylation of CpG islands in human cancer
remain almost completely unknown. We used a methylation‐sensitive arbitrarily primed …

Several studies have reported that elevated MMP-9 expression in lymphoma tissues
correlated with tumor stage, grade, or prognosis. Because the DNA methylation pattern is …

The analysis of genomic alterations in acute lymphoblastic leukemia (ALL) has provided
new insights for prognosis and possible targets of novel therapies. In T-ALL the role of …

Transcription factors play a crucial role during hematopoiesis by orchestrating lineage
commitment and determining cellular fate. Although tight regulation of transcription factor …

The drivers of abnormal DNA methylation in human cancers include widespread aberrant
splicing of the DNMT3B gene, producing abnormal transcripts that encode truncated …