Abstract The von Hippel-Lindau tumour suppressor gene (VHL) targets hypoxia inducible
factor (HIF)-α subunits for ubiquitin dependent proteolysis. To better understand the role of …

Inactivation of the von Hippel-Lindau tumor suppressor gene is linked to the development of
hereditary (VHL Disease-associated) and sporadic clear cell carcinoma of the kidney. The …

Abstract von Hippel–Lindau (VHL) disease is a hereditary tumor syndrome predisposing to
multifocal bilateral renal cell carcinomas (RCCs), pheochromocytomas, and pancreatic …

Clear-cell renal carcinoma is associated with inactivation of the von Hippel-Lindau (VHL)
tumor suppressor gene. VHL is the substrate recognition subunit of an E3 ligase, known to …

Inactivating mutations within the von Hippel-Lindau (VHL) tumor suppressor gene
predispose patients to develop a variety of highly vascularized tumors. pVHL targets α …

Bi-allelic-inactivating mutations of the VHL tumor suppressor gene are found in the majority
of clear cell renal cell carcinomas (VHL-/-RCC). VHL-/-RCC cells overproduce hypoxia …

Abstract The von Hippel-Lindau tumor suppressor, pVHL, is a key player in one of the best
characterized hypoxia signaling pathways, the VHL-hypoxia-inducible factor (VHL-HIF) …

The VHL tumor suppressor gene has previously been reported to encode a protein of 213
amino acid residues. Here we report the identification of a second major VHL gene product …

Biallelic inactivating mutations of the von Hippel-Lindau tumor suppressor gene (VHL) are a
hallmark of clear cell renal cell carcinoma (CCRCC), the most common histologic subtype of …

The VHL (von Hippel–Lindau) tumour-suppressor gene is inactivated in VHL disease and in
sporadic cases of CCRCC [clear-cell RCC (renal cell carcinoma)]. pVHL (VHL protein) …