Absence of VHL gene alteration and high VEGF expression are associated with tumour aggressiveness and poor survival of renal-cell carcinoma
JJ Patard, N Rioux-Leclercq, D Masson… - British journal of …, 2009 - nature.com
Background: The von Hippel–Lindau gene (VHL) alteration, a common event in sporadic
clear-cell renal-cell carcinoma (CCRCC), leads to highly vascularised tumours. Vascular …
clear-cell renal-cell carcinoma (CCRCC), leads to highly vascularised tumours. Vascular …
Vascular endothelial growth factor overexpression is correlated with von Hippel‐Lindau tumor suppressor gene inactivation in patients with sporadic renal cell …
H Igarashi, M Esumi, H Ishida, K Okada - Cancer, 2002 - Wiley Online Library
In the current study, the authors found a correlation between vascular endothelial growth
factor (VEGF) overexpression and both biallelic and monoallelic von Hippel‐Lindau (VHL) …
factor (VEGF) overexpression and both biallelic and monoallelic von Hippel‐Lindau (VHL) …
Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: Relationship to clinicopathological parameters
K Kondo, M Yao, M Yoshida, T Kishida… - Genes …, 2002 - Wiley Online Library
To delineate more precisely the somatic von Hippel-Lindau disease (VHL) gene alteration
as well as to elucidate its etiologic role in renal tumorigenesis, we examined a total of 240 …
as well as to elucidate its etiologic role in renal tumorigenesis, we examined a total of 240 …
Mutations of the VHL tumour suppressor gene in renal carcinoma
JR Gnarra, K Tory, Y Weng, L Schmidt, MH Wei, H Li… - Nature …, 1994 - nature.com
Multiple, bilateral renal carcinomas are a frequent occurrence in von Hippel–Lindau (VHL)
disease. To elucidate the aetiological role of the VHL gene in human kidney tumorigenesis …
disease. To elucidate the aetiological role of the VHL gene in human kidney tumorigenesis …
VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment
WK Rathmell, S Chen - Expert review of anticancer therapy, 2008 - Taylor & Francis
Clear cell renal cell carcinoma (ccRCC) provides a tumor paradigm for the integration of
genetics, molecular biology, therapeutic target validation and the introduction of high-impact …
genetics, molecular biology, therapeutic target validation and the introduction of high-impact …
pVHL function is essential for endothelial extracellular matrix deposition
The tumor suppressor von Hippel-Lindau protein (pVHL) is critical for cellular molecular
oxygen sensing, acting to target degradation of the hypoxia-inducible factor alpha …
oxygen sensing, acting to target degradation of the hypoxia-inducible factor alpha …