Oxytocin receptor genetic and epigenetic variations: association with child abuse and adult psychiatric symptoms

EL Smearman, LM Almli, KN Conneely… - Child …, 2016 - Wiley Online Library
Childhood abuse can alter biological systems and increase risk for adult psychopathology.
Epigenetic mechanisms, alterations in DNA structure that regulate the gene expression, are …

Examining the link between emotional childhood abuse and social relationships in midlife: The moderating role of the oxytocin receptor gene

AM Ebbert, FJ Infurna, SS Luthar… - Child abuse & …, 2019 - Elsevier
Background A single nucleotide polymorphism (SNP), rs53576, of the oxytocin receptor
gene (OXTR) has been associated with fundamental aspects of social processes and …

Polymorphisms in the oxytocin receptor gene are associated with the development of psychopathy

MR Dadds, C Moul, A Cauchi… - Development and …, 2014 - cambridge.org
The co-occurrence of child conduct problems (CPs) and callous–unemotional (CU) traits
confers risk for psychopathy. The oxytocin (OXT) system is a likely candidate for involvement …

[HTML][HTML] Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies

EJ Kraaijenvanger, Y He, H Spencer, AK Smith… - Neuroscience & …, 2019 - Elsevier
The human oxytocin (OXT) system is implicated in the regulation of complex social
behaviors, as well as in psychopathologies characterized by social deficits. Emerging …

Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: moderation by oxytocin receptor …

B Bradley, D Westen, KB Mercer, EB Binder… - Development and …, 2011 - cambridge.org
The ability to effectively regulate emotions and a secure attachment style are critical for
maintaining mental health across the life span. The experience of childhood maltreatment …

Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls

RJ Thompson, KJ Parker, JF Hallmayer… - …, 2011 - Elsevier
The nonapeptide oxytocin and its receptor have been implicated in the regulation of
mammalian social behavior and stress physiology. Evidence is accumulating that the quality …

Methylation of the oxytocin receptor gene and oxytocin blood levels in the development of psychopathy

MR Dadds, C Moul, A Cauchi… - Development and …, 2014 - cambridge.org
Child conduct problems (CPs) are a robust predictor of adult mental health; the concurrence
of callous–unemotional (CU) traits confers specific risk for psychopathy. Psychopathy may …

The role of oxytocin and oxytocin receptor gene variants in childhood‐onset aggression

AI Malik, CC Zai, Z Abu, B Nowrouzi… - Genes, brain and …, 2012 - Wiley Online Library
Aggressive antisocial behaviours are the most common reasons why adolescents are
referred to mental health clinics. Antisocial behaviours are costly in social and financial …

Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress

AJ Myers, L Williams, JM Gatt, EZ McAuley-Clark… - Journal of psychiatric …, 2014 - Elsevier
Background Oxytocin is a neuropeptide that is involved in the regulation of mood, anxiety
and social biology. Genetic variation in the oxytocin receptor gene (OXTR) has been …

Association between the oxytocin receptor (OXTR) gene and children's social cognition at 18 months

M Wade, TJ Hoffmann, K Wigg… - Genes, Brain and …, 2014 - Wiley Online Library
At 18 months, children engage in a variety of social behaviors that reflect their nascent ability
to understand the intentions of other people (eg joint attention, empathy, cooperation and …