Two waves of DNA methylation reprogramming occur during mammalian embryogenesis;
during preimplantation development and during primordial germ cell (PGC) formation …

Methylation of cytosines in the CG context (mCG) is the most abundant DNA modification in
vertebrates that plays crucial roles in cellular differentiation and identity. After fertilization …

Epigenetic reprogramming of parental genomes following fertilization is important to ensure
compatibility for totipotency and development thereafter. New studies by Jiang et al. and …

DNA methylation is a major epigenetic modification that undergoes dramatic changes in two
epigenetic reprogramming windows during development: first in preimplantation embryos …

DNA methylation is dynamically remodelled during the mammalian life cycle through distinct
phases of reprogramming and de novo methylation. These events enable the acquisition of …

The germline is the only cellular lineage capable of transferring genetic information from one
generation to the next. Intergenerational transmission of epigenetic memory through the …

DNA methylation occurs on cytosines, is catalyzed by DNA methyltransferases (DNMTs),
and is present at high levels in all vertebrates. DNA methylation plays essential roles in …

Post-fertilization epigenome reprogramming erases epigenetic marks transmitted through
gametes and establishes new marks during mid-blastula stages. The mouse embryo …

DNA methylation undergoes dynamic changes during development and cell differentiation.
Recent genome-wide studies discovered that tissue-specific differentially methylated …

DNA methylation is a prevalent epigenetic modification in vertebrates, and it has been
shown to be involved the regulation of gene expression and embryo development. However …