[HTML][HTML] Epigenetic regulation of peroxisome proliferator-activated receptor gamma mediates high-fat diet-induced non-alcoholic fatty liver disease

T Hajri, M Zaiou, TV Fungwe, K Ouguerram, S Besong - Cells, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in Western countries and has
become a serious public health concern. Although Western-style dietary patterns …

[HTML][HTML] Peroxisome proliferator-activated receptor-γ as a target and regulator of epigenetic mechanisms in nonalcoholic fatty liver disease

M Zaiou - Cells, 2023 - mdpi.com
Peroxisome proliferator-activated receptor-γ (PPARγ) belongs to the superfamily of nuclear
receptors that control the transcription of multiple genes. Although it is found in many cells …

[HTML][HTML] Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

M Régnier, A Polizzi, S Smati, C Lukowicz… - Scientific reports, 2020 - nature.com
Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to
orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid …

Loss of Hepatocyte‐Specific PPARγ Expression Ameliorates Early Events of Steatohepatitis in Mice Fed the Methionine and Choline‐Deficient Diet

J Cordoba-Chacon - PPAR research, 2020 - Wiley Online Library
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. To date,
there is not a specific and approved treatment for NAFLD yet, and therefore, it is important to …

[HTML][HTML] Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARγ expression

L Li, J Fu, D Liu, J Sun, Y Hou, C Chen, J Shao… - Redox biology, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is an emerging global disease with increasing
prevalence. However, the mechanism of NAFLD development is not fully understood. To …

Reduced expression of peroxisome proliferator‐activated receptor‐α may have an important role in the development of non‐alcoholic fatty liver disease

JE Yeon, KM Choi, SH Baik, KO Kim… - Journal of …, 2004 - Wiley Online Library
Background: Although the pathogenesis of non‐alcoholic fatty liver disease (NAFLD)
remains poorly understood, metabolic syndrome associated with insulin resistance is the …

[HTML][HTML] Changes in peroxisome proliferator-activated receptor alpha target gene expression in peripheral blood mononuclear cells associated with non-alcoholic fatty …

TT Li, TB Tan, HQ Hou, XY Zhao - Lipids in health and disease, 2018 - Springer
Objective To identify differences in the expression of peroxisome proliferator-activated
receptor alpha (PPARα) target genes in human peripheral blood mononuclear cells …

[PDF][PDF] Novel aspects of PPARα‐mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study

PGP Martin, H Guillou, F Lasserre, S Déjean… - …, 2007 - Wiley Online Library
Peroxisome proliferator‐activated receptor‐α (PPARα) is a major transcriptional regulator of
lipid metabolism. It is activated by diverse chemicals such as fatty acids (FAs) and regulates …

An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high …

T Yamazaki, S Shiraishi, K Kishimoto, S Miura… - The Journal of nutritional …, 2011 - Elsevier
The effects of a diet rich in saturated fat on fatty liver formation and the related mechanisms
that induce fatty liver were examined. C57BL/6J mice were fed butter or safflower oil as a …

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

A Montagner, A Polizzi, E Fouché, S Ducheix, Y Lippi… - Gut, 2016 - gut.bmj.com
Objective Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor
expressed in tissues with high oxidative activity that plays a central role in metabolism. In …