Context: It is not known whether there are any DNA methylation alterations in adrenocortical
tumors. Objective: The objective of the study was to determine the methylation profile of …

The molecular pathogenesis of benign and malignant adrenocortical tumors (ACT) is
incompletely clarified. The role of DNA methylation in adrenocortical tumorigenesis has not …

Context: Adrenocortical cancer (ACC) is an aggressive tumor with a heterogeneous
outcome. Prognostic stratification is difficult even based on tumor stage and Ki67. Recently …

Purpose: DNA methylation is a mechanism for gene expression silencing in cancer. Limited
information is available for adrenocortical tumors. Abnormal methylation at the IGF2/H19 …

Context Adrenocortical carcinomas (ACC) are a rare tumor type with a poor five-year
survival rate and limited treatment options. Objective Understanding of the molecular …

DNA methylation profiling has been suggested a reliable technique to distinguish between
benign and malignant adrenocortical tumors, a process which with current diagnostic …

Objective: Our objective was to determine whether any changes in methylation are
associated with aldosteronomas. Methods: We performed integrated genome-wide …

Context Adrenocortical carcinoma (ACC) is a rare aggressive disease with heterogeneous
prognoses. Previous studies identified hypermethylation in the promoter region of specific …

The role of DNA methylation of CpG islands in parathyroid tumorigenesis has not been
analyzed in an unbiased, systematic fashion. DNA was isolated from normal and pathologic …

Objective: The purpose of this study was to determine the global patterns of aberrant DNA
methylation in thyroid cancer. Research Design and Methods: We have used DNA …