Genome-wide hypomethylation in hepatocellular carcinogenesis
CH Lin, SY Hsieh, IS Sheen, WC Lee, TC Chen… - Cancer research, 2001 - AACR
Aberrant genome-wide hypomethylation has been thought to be related to tumorigenesis.
However, its mechanism and implications in hepatocellular carcinogenesis remain to be …
However, its mechanism and implications in hepatocellular carcinogenesis remain to be …
Definition of the landscape of promoter DNA hypomethylation in liver cancer
B Stefanska, J Huang, B Bhattacharyya, M Suderman… - Cancer research, 2011 - AACR
We use hepatic cellular carcinoma (HCC), one of the most common human cancers, as a
model to delineate the landscape of promoter hypomethylation in cancer. Using a …
model to delineate the landscape of promoter hypomethylation in cancer. Using a …
Concordance of DNA methylation pattern in plasma and tumor DNA of Egyptian hepatocellular carcinoma patients
P Iyer, AR Zekri, CW Hung, E Schiefelbein… - … and molecular pathology, 2010 - Elsevier
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the fourth leading
cause of cancer mortality globally. HCC incidence has doubled in Egypt in the past 10 years …
cause of cancer mortality globally. HCC incidence has doubled in Egypt in the past 10 years …
Identification of genes preferentially methylated in hepatitis C virus‐related hepatocellular carcinoma
YB Deng, G Nagae, Y Midorikawa, K Yagi… - Cancer …, 2010 - Wiley Online Library
Chronic infections by hepatitis B virus (HBV) and hepatitis C virus (HCV) appear to be the
most significant causes of hepatocellular carcinoma (HCC). Aberrant promoter methylation …
most significant causes of hepatocellular carcinoma (HCC). Aberrant promoter methylation …
[HTML][HTML] Meta-analysis of DNA methylation biomarkers in hepatocellular carcinoma
DNA methylation is an epigenetic mechanism in the pathogenesis of hepatocellular
carcinoma (HCC). Here, we conducted a systematic meta-analysis to evaluate the …
carcinoma (HCC). Here, we conducted a systematic meta-analysis to evaluate the …
[PDF][PDF] DNA methylation‐based prognosis and epidrivers in hepatocellular carcinoma
A Villanueva, A Portela, S Sayols, C Battiston… - …, 2015 - Wiley Online Library
Epigenetic deregulation has emerged as a driver in human malignancies. There is no clear
understanding of the epigenetic alterations in hepatocellular carcinoma (HCC) and of the …
understanding of the epigenetic alterations in hepatocellular carcinoma (HCC) and of the …
DNA methylation markers for diagnosis and prognosis of common cancers
X Hao, H Luo, M Krawczyk, W Wei… - Proceedings of the …, 2017 - National Acad Sciences
The ability to identify a specific cancer using minimally invasive biopsy holds great promise
for improving the diagnosis, treatment selection, and prediction of prognosis in cancer …
for improving the diagnosis, treatment selection, and prediction of prognosis in cancer …
Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
S Lee, HJ Lee, JH Kim, HS Lee, JJ Jang… - The American journal of …, 2003 - Elsevier
To determine the methylation profile of multiple tumor-related genes during multistep
hepatocarcinogenesis, we investigated the methylation status of CpG islands of 9 genes …
hepatocarcinogenesis, we investigated the methylation status of CpG islands of 9 genes …
[PDF][PDF] Hepatocellular carcinoma detection by plasma methylated DNA: discovery, phase I pilot, and phase II clinical validation
Early detection improves hepatocellular carcinoma (HCC) outcomes, but better noninvasive
surveillance tools are needed. We aimed to identify and validate methylated DNA markers …
surveillance tools are needed. We aimed to identify and validate methylated DNA markers …
Cell-free DNA methylation markers for differential diagnosis of hepatocellular carcinoma
B Luo, F Ma, H Liu, J Hu, L Rao, C Liu, Y Jiang… - BMC medicine, 2022 - Springer
Background Aberrant DNA methylation may offer opportunities in revolutionizing cancer
screening and diagnosis. We sought to identify a non-invasive DNA methylation-based …
screening and diagnosis. We sought to identify a non-invasive DNA methylation-based …