Aberrant genome-wide hypomethylation has been thought to be related to tumorigenesis.
However, its mechanism and implications in hepatocellular carcinogenesis remain to be …

We use hepatic cellular carcinoma (HCC), one of the most common human cancers, as a
model to delineate the landscape of promoter hypomethylation in cancer. Using a …

Hepatocellular carcinoma (HCC) is the fifth most common cancer and the fourth leading
cause of cancer mortality globally. HCC incidence has doubled in Egypt in the past 10 years …

Chronic infections by hepatitis B virus (HBV) and hepatitis C virus (HCV) appear to be the
most significant causes of hepatocellular carcinoma (HCC). Aberrant promoter methylation …

DNA methylation is an epigenetic mechanism in the pathogenesis of hepatocellular
carcinoma (HCC). Here, we conducted a systematic meta-analysis to evaluate the …

Epigenetic deregulation has emerged as a driver in human malignancies. There is no clear
understanding of the epigenetic alterations in hepatocellular carcinoma (HCC) and of the …

The ability to identify a specific cancer using minimally invasive biopsy holds great promise
for improving the diagnosis, treatment selection, and prediction of prognosis in cancer …

To determine the methylation profile of multiple tumor-related genes during multistep
hepatocarcinogenesis, we investigated the methylation status of CpG islands of 9 genes …

Early detection improves hepatocellular carcinoma (HCC) outcomes, but better noninvasive
surveillance tools are needed. We aimed to identify and validate methylated DNA markers …

Background Aberrant DNA methylation may offer opportunities in revolutionizing cancer
screening and diagnosis. We sought to identify a non-invasive DNA methylation-based …