We performed a global methylation profiling assay on 1505 CpG sites across 807 genes to
characterize DNA methylation patterns in pancreatic cancer genome. We found 289 CpG …

To address the shortcomings of current hepatocellular carcinoma (HCC) surveillance tests,
we set out to find HCC-specific methylation markers and develop a highly sensitive …

The alteration of DNA methylation landscape is a key epigenetic event in cancer. As the
accumulation of large-scale genome-wide DNA methylation data from clinical samples, we …

Background The development of colorectal cancer (CRC) is accompanied by extensive
epigenetic changes, including frequent regional hypermethylation particularly of gene …

An abnormal pattern of DNA methylation occurs at specific genes in almost all neoplasms.
The lack of high-throughput methods with high specificity and sensitivity to detect changes in …

DNA methylation is a promising biomarker for cancer. This study was aimed at investigating
the methylation levels of multiple genes in hepatocellular carcinoma (HCC) and to identify a …

Abstract Background: Hypermethylation of a CpG-rich promoter (CpG island) blocks
expression of the corresponding gene. The CpG island methylator phenotype (CIMP) …

Alterations of DNA methylation, which result in chromosomal instability and silencing of
tumor‐related genes, are among the most consistent epigenetic changes observed in …

Background Aberrant methylation of DNA is a key driver of hepatocellular carcinoma (HCC).
In this study, we sought to integrate four cohorts profile datasets to identify such abnormally …

For appropriate surveillance of patients at the precancerous stage for hepatocellular
carcinomas (HCCs), carcinogenetic risk estimation is advantageous. The aim of our study …