Background We performed a genome-wide scan of 27,578 CpG loci covering 14,475 genes
to identify differentially methylated loci (DML) in colorectal carcinoma (CRC). Methods We …

Purpose: The goal of this study was to comprehensively identify CpG island methylation
alterations between pancreatic cancers and normal pancreata and their associated gene …

Cancer-specific DNA methylation from the tumor derived fraction of cell free DNA found in
blood samples could be used for minimally invasive detection and monitoring of cancer. The …

Global changes in DNA methylation correlate with altered gene expression and genomic
instability in cancer. We have developed a methylation-specific digital sequencing (MSDS) …

We have developed a transcriptome-wide approach to identify genes affected by promoter
CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By …

To investigate whether aberrant hypermethylation in plasma DNA could be used as
diagnosis makers for hepatocellular carcinoma (HCC), we performed methylation-specific …

Aberrant DNA methylation of CpG sites is among the earliest and most frequent alterations
in cancer. Several studies suggest that aberrant methylation occurs in a tumour type-specific …

Aberrant DNA methylation and increased expression of DNA methyltransferases (DNMTs)
are features of tumor cells. To investigate roles for DNMTs during hepatocarcinogenesis, we …

Metastases in the later stages of hepatocellular carcinoma (HCC) cause the majority of
deaths associated with the disease, making early detection crucial to patient survival. Risk …

Background With the development of high-throughput screening, a variety of genetic
alterations has been found in hepatocellular carcinoma (HCC). Although previous studies …