Pharmacokinetic, pharmacodynamic and pharmacogenomic studies of midazolam are
currently being performed in critically ill children to find suitable dose regimens. Sensitive …

We have developed a sensitive, selective and reproducible reversed-phase high-
performance liquid chromatography method coupled with electrospray ionization mass …

Aim To compare the clearance of midazolam and its metabolites in critically ill paediatric and
adult patients. Method A prospective study conducted in paediatric and adult intensive care …

Midazolam is metabolized by the developmentally regulated intestinal and hepatic drug‐
metabolizing enzyme cytochrome P450 (CYP) 3A4/5. It is frequently administered orally to …

A highly sensitive liquid chromatography–tandem mass spectrometry method for the
simultaneous quantification of midazolam and its major metabolites 1′‐hydroxymidazolam …

Interventions The pharmacokinetics of midazolam and metabolites were determined during
and after a continuous infusion of midazolam (0.05–0.4 mg/kg/hr) for 3.8 hrs to 25 days …

A sensitive and selective gas chromatographic mass spectrometric method for the
determination of midazolam and its biologically active metabolite, 1-hydroxymidazolam, in …

Growth and development affect drug‐metabolizing enzyme activity thus could alter the
metabolic profile of a drug. Traditional studies to create metabolite profiles and study the …

Currently, pharmacokinetic–pharmacodynamic studies of sedatives and analgesics are
performed in neonates and children to find suitable dose regimens. As a result, sensitive …

A simple, selective high‐performance liquid chromatographic method with ultraviolet
detection at 220nm is described for quantitation of midazolam and its primary metabolite 1 …