[HTML][HTML] CRISPR in context: towards a socially responsible debate on embryo editing

M Morrison, S de Saille - Palgrave Communications, 2019 - nature.com
Following the birth in 2018 of two babies from embryos altered using CRISPR-Cas9, human
germline gene editing (GGE) moved from abstract concern to reality. He Jiankui, the scientist …

The wisdom of germline editing: an ethical analysis of the use of CRISPR-Cas9 to edit human embryos

JM Gumer - The New Bioethics, 2019 - Taylor & Francis
With recent reports that a Chinese scientist used CRISPR-Cas9 to heritably edit the
genomes of human embryos (ie, germline editing) brought to term, discussions regarding …

Focusing on Human Rights: a framework for CRISPR germline genome editing ethics and regulation

K Doxzen, J Halpern - Perspectives in Biology and Medicine, 2020 - muse.jhu.edu
abstract The late 2018 announcement of the claimed births of CRISPR-edited babies has
stimulated widespread condemnation and calls by some leading scientists for a moratorium …

[HTML][HTML] Human germline interventions–think first

E Hildt - Frontiers in genetics, 2016 - frontiersin.org
Recent studies using gene editing tools such as CRISPR/Cas9 have shown an enormously
broad spectrum of possible future applications. This genetic engineering technique allows …

CRISPR babies: a view from the centre of the storm

R Lovell-Badge - Development, 2019 - journals.biologists.com
Towards the end of November 2018, news broke that the Chinese researcher He Jiankui
had created the world's first genome-edited babies. This came shortly before the start of the …

Ethics and germline gene editing

J Sugarman - EMBO reports, 2015 - embopress.org
The current kerfuffle around the use of CRISPR/Cas9 and other gene editing technologies in
human germline research is the latest in a series of related controversies at the intersection …

[HTML][HTML] CRISPR-Cas and its wide-ranging applications: From human genome editing to environmental implications, technical limitations, hazards and bioethical …

R Piergentili, A Del Rio, F Signore, F Umani Ronchi… - Cells, 2021 - mdpi.com
The CRISPR-Cas system is a powerful tool for in vivo editing the genome of most organisms,
including man. During the years this technique has been applied in several fields, such as …

[HTML][HTML] Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic

R Ranisch, K Trettenbach, G Arnason - Medicine, Health Care and …, 2023 - Springer
Abstract Following the Second Summit on Human Gene Editing in Hong Kong in 2018,
where the birth of two girls with germline genome editing was revealed, the need for a …

CRISPR/Cas9 genome editing–new and old ethical issues arising from a revolutionary technology

M Baumann - NanoEthics, 2016 - Springer
Although germline editing has been the subject of debate ever since the 1980s, it tended to
be based rather on speculative assumptions until April 2015, when CRISPR/Cas9 …

[HTML][HTML] # CRISPRbabies: notes on a scandal

SP Ryder - The CRISPR Journal, 2018 - liebertpub.com
Like almost everyone, I was stunned by the birth announcement of genetically modified
twins, Lulu and Nana. A Tweet pointed me to the MIT Technology Review scoop1 that, along …