I respectfully propose this neologism because it serves to formally unite the study of DNA
methylation with the power of modern genomics. At this writing, the word does not appear in …

DNA methylation at the CpG dinucleotide is considered a stable epigenetic mark due to its
presumed long-term inheritance through clonal expansion. Here, we perform high …

To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …

Hypermethylation is associated with the silencing of tumour susceptibility genes in several
forms of cancer,; however, the mechanisms responsible for this aberrant methylation are …

Putting the DNA back into DNA methylation | Nature Genetics Skip to main content Thank you
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DNA in somatic tissue is characterized by a bimodal pattern of methylation, which is
established in the animal through a series of developmental events 1. In the mouse blastula …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …

Inactivation of tumour suppressor genes is central to the development of all common forms
of human cancer 1. This inactivation often results from epigenetic silencing associated with …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

Alterations in DNA methylation (DNAm) in cancer have been known for 25 years, including
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …