The identification of optimal methylation biomarkers to achieve maximum diagnostic ability
remains a challenge. The present study aimed to elucidate the potential molecular …

Background The study aimed to analyze aberrantly methylated genes, relevant pathways
and transcription factors (TFs) in osteosarcoma (OS) development. Methods Based on the …

Osteosarcoma is a common malignant tumor in childhood and adolescence (nearly 5% of all
cases of cancer in children), as well as a type of tumor with poor prognosis. However, the …

Numerous reports have demonstrated that DNA methylation may be underlying prognostic
biomarkers of cancer. However, few studies indicated that DNA methylation was …

Aberrant methylation of genomic DNA has been reported in many cancers. Specific DNA
methylation patterns have been shown to provide clinically useful prognostic information …

Background Osteosarcoma (OS) is the most common primary bone tumors diagnosed in
children and adolescents. Recent studies have shown a prognostic role of DNA methylation …

Osteosarcoma (OS) is the commonest malignant bone tumor in adolescent patients, and
patients face amputation, tumor metastasis, chemotherapy resistance, and even death. We …

Osteosarcoma (OS) is a common primary malignancy in children and adolescents with
relative high survival rate after chemotherapy. While, the toxicity of chemotherapy and …

Genetic and epigenetic changes contribute to deregulation of gene expression and
development of human cancer. Changes in DNA methylation are key epigenetic factors …

Osteosarcoma (OS) is one of the most common types of primary bone tumors in early
adolescence with unsatisfied prognosis. Aberrant DNA methylation had been demonstrated …