The methyl-CpG binding domain and the evolving role of DNA methylation in animals
B Hendrich, S Tweedie - TRENDS in Genetics, 2003 - cell.com
DNA methylation occurs in bacteria, fungi, plants and animals, however its role varies widely
among different organisms. Even within animal genomes, methylation patterns vary …
among different organisms. Even within animal genomes, methylation patterns vary …
Studies of DNA methylation in animals
We have been studying the evolution and function of DNA methylation in vertebrate animals
using three related approaches. The first is to further characterise proteins that bind to …
using three related approaches. The first is to further characterise proteins that bind to …
[HTML][HTML] Comparative study of methyl-CpG-binding domain proteins
TC Roloff, HH Ropers, UA Nuber - BMC genomics, 2003 - Springer
Abstract Background Methylation at CpG dinucleotides in genomic DNA is a fundamental
epigenetic mechanism of gene expression control in vertebrates. Proteins with a methyl …
epigenetic mechanism of gene expression control in vertebrates. Proteins with a methyl …
Methyl‐CpG‐binding proteins: Targeting specific gene repression
E Ballestar, AP Wolffe - European journal of biochemistry, 2001 - Wiley Online Library
CpG methylation, the most common epigenetic modification of vertebrate genomes, is
primarily associated with transcriptional repression. MeCP2, MBD1, MBD2, MBD3 and …
primarily associated with transcriptional repression. MeCP2, MBD1, MBD2, MBD3 and …
Transcription factors as readers and effectors of DNA methylation
Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …
base-pair resolution under various physiological conditions. Many aberrant or differentially …
[HTML][HTML] Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1
I Ohki, N Shimotake, N Fujita, M Nakao… - The EMBO …, 1999 - embopress.org
CpG methylation in vertebrates is important for gene silencing, alterations in chromatin
structure and genomic stability, and differences in the DNA-methylation status are correlated …
structure and genomic stability, and differences in the DNA-methylation status are correlated …
[HTML][HTML] DNA methylation and methyl-CpG binding proteins: developmental requirements and function
O Bogdanović, GJC Veenstra - Chromosoma, 2009 - Springer
DNA methylation is a major epigenetic modification in the genomes of higher eukaryotes. In
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …
[PDF][PDF] Many paths to one goal? The proteins that recognize methylated DNA in eukaryotes
N Sasai, PA Defossez - International Journal of Developmental …, 2009 - researchgate.net
ABSTRACT DNA methylation is an epigenetically inherited chemical modification that is
associated with transcriptional silencing and is essential for mammalian development. The …
associated with transcriptional silencing and is essential for mammalian development. The …
Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA
Methylated DNA in vertebrates is associated with transcriptional repression and inactive
chromatin. Two activities have been identified, MeCP1 and MeCP2, which bind specifically …
chromatin. Two activities have been identified, MeCP1 and MeCP2, which bind specifically …
On how mammalian transcription factors recognize methylated DNA
BA Buck-Koehntop, PA Defossez - Epigenetics, 2013 - Taylor & Francis
DNA methylation is an epigenetic mark that is essential for the development of mammals; it
is frequently altered in diseases ranging from cancer to psychiatric disorders. The presence …
is frequently altered in diseases ranging from cancer to psychiatric disorders. The presence …
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