Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

Post-translational modification of chromatin is emerging as an increasingly important
regulator of chromosomal processes. In particular, histone lysine and arginine methylation …

Eukaryotic chromatin can be highly dynamic and can continuously exchange between an
open transcriptionally active conformation and a compacted silenced one. Post-translational …

Nucleosomal histones can be methylated in vivo at multiple residues and defined
methylation patterns are related to distinct functional readouts of chromosomal DNA. Histone …

Over the past year or so, methylation of histones has come to be recognised as a major
player in the regulation of gene activity. This notion follows the discovery of lysine and …

'Epigenetics' has been defined as the study of 'mitotically and/or meiotically heritable
changes in gene function that cannot be explained by changes in DNA sequence' …

Although the field of genetics has grown by leaps and bounds within the last decade due to
the completion and availability of the human genome sequence, transcriptional regulation …

Aging induces myriad cellular and, ultimately, physiological changes that cause a decline in
an organism's functional capabilities. Although the aging process and the pathways that …

Methylation of histones mediates transcriptional silencing at heterochromatin sites and
affects regulated transcription at euchromatic loci. So is the methyl group a permanent mark …

Epigenetics is the study of heritable changes in gene expression that are not mediated at the
DNA sequence level. Molecular mechanisms that mediate epigenetic regulation include …