How developmental gene expression is activated, co-ordinated and maintained is one of the
biggest questions in developmental biology. While transcription factors lead the way in …

The generation of complex organisms requires that an initial population of cells with
identical gene expression profiles can adopt different cell fates during development by …

Early animal development is characterized by intense reorganization of the embryonic
genome, including large-scale changes in chromatin structure and in the DNA and histone …

The complex processes necessary for embryogenesis require a gene regulatory network
that is complex and systematic. Gene expression regulates development and …

Reversible covalent histone modifications are known to influence spatiotemporal patterns of
gene transcription during development. Here I review recent advances in the development …

Background Cell fate decisions are governed by interactions between sequence‐specific
transcription factors and a dynamic chromatin landscape. Zebrafish offer a powerful system …

Complex multi-cellular organisms are shaped starting from a single-celled zygote, owing to
elaborate developmental programs. These programs involve several layers of regulation to …

Multicellular development is programmed by regulated interactions between transcription
factors and target genes. Target genes function as nucleosomal arrays whose higher order …

Upon fertilization, the genome of animal embryos remains transcriptionally inactive until the
maternal-to-zygotic transition. At this time, the embryo takes control of its development and …

Early vertebrate embryos must achieve totipotency and prepare for zygotic genome
activation (ZGA). To better understand, we determined DNAme profiles of zebrafish …