Alterations in global DNA methylation and hydroxymethylation are not detected in A lzheimer's disease

T Lashley, P Gami, N Valizadeh, A Li… - Neuropathology and …, 2015 - Wiley Online Library
Aims Genetic factors do not seem to account fully for A lzheimer disease (AD) pathogenesis.
There is evidence for the contribution of environmental factors, whose effect may be …

Epigenetics in Alzheimer's disease: perspective of DNA methylation

TJ Qazi, Z Quan, A Mir, H Qing - Molecular Neurobiology, 2018 - Springer
Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

[PDF][PDF] DNA methylation alterations in Alzheimer's disease

AS Yokoyama, JC Rutledge… - Environmental epigenetics, 2017 - academic.oup.com
The observation that Alzheimer's disease (AD) patients with similar and even identical
genetic backgrounds often present with heterogeneous pathologies has prompted the …

Epigenetic modifications in Alzheimer's disease: cause or effect?

I Piaceri, B Raspanti, A Tedde… - Journal of …, 2014 - journals.sagepub.com
Alzheimer's disease (AD) is a multifactorial disorder induced by a combination of genetic
and environmental factors, and epigenetic modifications could be the key to understand the …

Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease

AJ Phipps, JC Vickers, PC Taberlay… - Neurobiology of Aging, 2016 - Elsevier
There is increasing evidence that epigenetic alterations may play a role in Alzheimer's
disease (AD); yet, there is little information regarding epigenetic modifications in specific cell …

[HTML][HTML] Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

L Chouliaras, D Mastroeni, E Delvaux, A Grover… - Neurobiology of …, 2013 - Elsevier
Epigenetic dysregulation of gene expression is thought to be critically involved in the
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation …

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

N Coppieters, BV Dieriks, C Lill, RLM Faull… - Neurobiology of …, 2014 - Elsevier
Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …

DNA methylation in Alzheimer's disease: In brain and peripheral blood

X Wei, L Zhang, Y Zeng - Mechanisms of Ageing and Development, 2020 - Elsevier
Alzheimer's disease (AD) is the most widespread neurodegenerative disorder and has
caused a major global health concern with the aging of the population. Recent studies have …

Epigenetics in Alzheimer's disease: a focus on DNA modifications

N Coppieters, M Dragunow - Current pharmaceutical design, 2011 - ingentaconnect.com
Epigenetic alterations have been associated with several human diseases including
Alzheimer's disease (AD). AD is a complex neurodegenerative disease characterized by a …

Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases

JAY Roubroeks, RG Smith… - Journal of …, 2017 - Wiley Online Library
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of
various neurodegenerative diseases. In this review, we discuss advances that have been …