The question of whether DNA methylation contributes to the stabilization of gene expression
patterns in differentiated mammalian tissues remains controversial. Using genome-wide …

Background DNA methylation is an important epigenetic control mechanism that has been
shown to be associated with gene silencing through the course of development, maturation …

DNA methylation is traditionally thought to be established during early development and to
remain mostly unchanged thereafter in healthy tissues, although recent studies have shown …

Remodelling the methylome is a hallmark of mammalian development and cell
differentiation. However, current knowledge of DNA methylation dynamics in human tissue …

Epigenetic regulation is essential in determining cellular phenotypes during differentiation.
Although tissue-specific DNA methylation has been studied, the significance of methylation …

DNA methylation patterns are set up in a relatively fixed programmed manner during normal
embryonic development and are then stably maintained. Using genome-wide analysis, we …

Abstract Development in mammals is accompanied by specific de novo and demethylation
events that are thought to stabilize differentiated cell phenotypes. We demonstrate that a …

To investigate the role of DNA methylation during human development, we developed
Methyl-seq, a method that assays DNA methylation at more than 90,000 regions throughout …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …