Autosomal dominant polycystic kidney disease (ADPKD) is typified by the accumulation of
fluid-filled cysts and abnormalities in renal epithelial cell function. The disease is principally …

Autosomal dominant polycystic kidney disease (ADPKD) is a common human genetic
disease characterized by cyst formation in kidney tubules and other ductular epithelia. Cells …

Polycystin-1 is a novel protein predicted to be a large membrane-spanning glycoprotein with
an extracellular N-terminus and an intracellular C-terminus, harboring several structural …

Polycystin-1 is a protein mutated in the majority of cases of autosomal dominant polycystic
kidney disease (ADPKD), but its role in the molecular pathway of tubulogenesis and …

The PKD1 protein, polycystin-1, is a large transmembrane protein of uncertain function and
topology. To study the putative functions of polycystin-1, conditionally immortalized kidney …

Polycystins are plasma membrane proteins that are expressed in kidney epithelial cells and
associated with the progression of ADPKD (autosomal dominant polycystic kidney disease) …

Background In a majority of cases, autosomal dominant polycystic kidney disease (ADPKD)
is caused by mutations within a putative open reading frame of the PKD1 gene. The …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of
fluid‐filled cysts in both kidneys, in addition to a variety of extra‐renal manifestations. The …

Mutations in the PKD1 gene are responsible for> 85% of autosomal dominant polycystic
kidney disease (ADPKD). The protein product of PKD1, polycystin-1, is a large, modular …

Cystogenesis associated with autosomal dominant polycystic kidney disease (ADPKD) is
characterized by perturbations in the polarized phenotype and function of cyst-lining …