The term epigenetics refers to the heritable changes in gene expression that are not
associated with a change in the actual DNA sequence. Epigenetic dysregulation is linked to …

Two nucleoside inhibitors of DNA methylation, azacitidine and decitabine, are now standard
of care for the treatment of the myelodysplastic syndrome, a deadly form of leukemia. These …

Aberrant DNA methylation patterns play an important role in the pathogenesis of
hematologic malignancies. The DNA methyltransferase inhibitors azacytidine and …

Gene silencing resulting from aberrant DNA methylation can lead to tumorigenesis.
Therefore, drugs that inhibit or interfere with DNA methylation have been used to reactivate …

PURPOSE OF THE REVIEW: Epigenetic changes marked by DNA methylation are known to
contribute to the malignant transformation of cells by silencing critical genes. Decitabine …

DNA methylation is responsible for abnormal silencing of many genes, including tumor
suppressor genes, in cancer. Decitabine, an S-phase specific inhibitor of DNA …

Epigenetic alterations, such as DNA methylation and histone modifications, are abnormal in
cancer cells, and the use of the hypomethylating agents 5-azacitidine and decitabine are …

Epigenetic changes such as DNA methylation act to regulate gene expression in normal
mammalian development. However, promoter hypermethylation also plays a major role in …

DNA methylation provides a major epigenetic code (besides histone modification) of the
lineage-and developmentspecific genes (such as regulators of differentiation in the …

BACKGROUND AND OBJECTIVES: Methylation of DNA is a common epigenetic
modification that plays an important role in the control of gene expression in mammalian …