DNA methylation plays a critical role in brain aging and Alzheimer's disease (AD). While
prior studies have largely focused on testing mean DNA methylation, DNA methylation …

The observation that Alzheimer's disease (AD) patients with similar and even identical
genetic backgrounds often present with heterogeneous pathologies has prompted the …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex …

Alzheimer's disease (AD) is the most common cause of dementia with advancing age as its
strongest risk factor. AD neuropathologic change (ADNC) is known to be associated with …

Introduction DNA methylation is a key epigenetic mechanism in brain aging and Alzheimer's
disease (AD). The newly discovered 5-hydroxymethylcytosine mediates DNA demethylation …

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …

The pathogenesis of Alzheimer's disease (AD) remains largely unclear. Exploring the
genetic/epigenetic loci showing pleiotropic association with the neuropathologies of AD may …

Late-onset Alzheimer's disease (AD) is a complex age-related neurodegenerative disorder
that likely involves epigenetic factors. To better understand the epigenetic state associated …

Background Alzheimer's disease is a progressive neurodegenerative disorder that is
hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in …

Background Growing evidence shows that epigenetic modifications play a role in
Alzheimer's disease (AD). We performed an epigenome-wide association study (EWAS) to …