Reduced expression of peroxisome proliferator‐activated receptor‐α may have an important role in the development of non‐alcoholic fatty liver disease

JE Yeon, KM Choi, SH Baik, KO Kim… - Journal of …, 2004 - Wiley Online Library
Background: Although the pathogenesis of non‐alcoholic fatty liver disease (NAFLD)
remains poorly understood, metabolic syndrome associated with insulin resistance is the …

[HTML][HTML] Peroxisome proliferator activated receptor-γ in pathogenesis of experimental fatty liver disease

CY Zhao, LL Jiang, L Li, ZJ Deng… - World Journal of …, 2004 - ncbi.nlm.nih.gov
AIM: To study the expression of peroxisome proliferator activated receptor-γ (PPARγ) in the
liver of rats with fatty liver disease (FLD) and to explore the role of PPARγ in the …

PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty‐acid metabolic enzymes

YS Seo, JH Kim, NY Jo, KM Choi… - Journal of …, 2008 - Wiley Online Library
Abstract Background and Aims: In a previous study, the authors found that reduced
expression of peroxisome proliferator‐activated receptor (PPAR)‐α might play an important …

Changes in peroxisome proliferator-activated receptor alpha target gene expression in peripheral blood mononuclear cells associated with non-alcoholic fatty liver …

TT Li, TB Tan, HQ Hou, XY Zhao - Lipids in health and disease, 2018 - Springer
Objective To identify differences in the expression of peroxisome proliferator-activated
receptor alpha (PPARα) target genes in human peripheral blood mononuclear cells …

Roles of peroxisome proliferator-activated receptor α in the pathogenesis of ethanol-induced liver disease

FG Meng, XN Zhang, SX Liu, YR Wang… - Chemico-Biological …, 2020 - Elsevier
Alcoholic liver disease (ALD) is a progressively aggravated liver disease with high incidence
in alcoholics. Ethanol-induced fat accumulation and the subsequent lipopolysaccharide …

[HTML][HTML] Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease

V Souza-Mello - World journal of hepatology, 2015 - ncbi.nlm.nih.gov
Lately, the world has faced tremendous progress in the understanding of non-alcoholic fatty
liver disease (NAFLD) pathogenesis due to rising obesity rates. Peroxisome proliferator …

[HTML][HTML] Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

M Pawlak, P Lefebvre, B Staels - Journal of hepatology, 2015 - Elsevier
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …

Genetic variation in the peroxisome proliferator activated receptor-gamma gene is associated with histologically advanced NAFLD

S Gawrieh, MC Marion, R Komorowski… - Digestive diseases and …, 2012 - Springer
Background The peroxisome proliferator activated receptor-gamma (PPARG) is a nuclear
receptor that regulates adipocyte differentiation, insulin sensitivity and lipid metabolism …

Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease

YJY Wan, M Morimoto, RG Thurman, HK Bojes… - Life Sciences, 1994 - Elsevier
Peroxisome proliferator-activated receptor (PPAR) and retinoid x receptor (RXR) play
important roles in fatty acid metabolism. The present study examined the regulation of …

[PDF][PDF] PPARα in the pathogenesis of fatty liver disease

M Sambasiva Rao, JK Reddy - Hepatology, 2004 - Wiley Online Library
See Article on Page 972. atty liver disease (FLD), which is emerging as the most common
liver disease in clinical practice, is F etiologically diverse and encompasses a morphological …