Extracellular vesicles, the cornerstone of next-generation cancer diagnosis?

J Weng, X Xiang, L Ding, ALA Wong, Q Zeng… - Seminars in cancer …, 2021 - Elsevier
Cancer has risen up to be a major cause of mortality worldwide over the past decades.
Despite advancements in cancer screening and diagnostics, a significant number of cancers …

Monitoring therapy efficiency in cancer through extracellular vesicles

I Stevic, G Buescher, FL Ricklefs - Cells, 2020 - mdpi.com
Extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed vesicles
made of a phospholipid bilayer and are secreted by all cell types. EVs are present in a …

Extracellular vesicles in cancer—implications for future improvements in cancer care

R Xu, A Rai, M Chen, W Suwakulsiri… - Nature reviews Clinical …, 2018 - nature.com
The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional
cell–cell communication within complex tissue environments. Such communication …

Towards the clinical implementation of extracellular vesicle-based biomarker assays for cancer

S Van Dorpe, P Tummers, H Denys… - Clinical Chemistry, 2024 - academic.oup.com
Background Substantial research has been devoted to elucidating the role of extracellular
vesicles (EVs) in the different hallmarks of cancer. Consequently, EVs are increasingly …

Diagnostic and therapeutic potential of extracellular vesicles in B-cell malignancies

E Gargiulo, PE Morande, A Largeot, E Moussay… - Frontiers in …, 2020 - frontiersin.org
Extracellular vesicles (EV), comprising microvesicles and exosomes, are particles released
by every cell of an organism, found in all biological fluids, and commonly involved in cell-to …

Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance

MH Vasconcelos, HR Caires, A Ābols… - Drug Resistance …, 2019 - Elsevier
Cancer-derived extracellular vesicles (EVs) have been detected in the bloodstream and
other biofluids of cancer patients. They carry various tumor-derived molecules such as …

Role of extracellular vesicles in hematological malignancies

S Raimondo, C Corrado, L Raimondi… - BioMed research …, 2015 - Wiley Online Library
In recent years the role of tumor microenvironment in the progression of hematological
malignancies has been widely recognized. Recent studies have focused on how cancer …

Extracellular vesicles in cancer: challenges and opportunities for clinical laboratories

Á González, S López-Borrego, A Sandúa… - Critical Reviews in …, 2024 - Taylor & Francis
Extracellular vesicles (EVs) are nano-sized particles secreted by most cells. They transport
different types of biomolecules (nucleic acids, proteins, and lipids) characteristic of their …

Proteomic analysis of extracellular vesicles for cancer diagnostics

AYT Wu, K Ueda, CPK Lai - Proteomics, 2019 - Wiley Online Library
Extracellular vesicles (EVs) including exosomes and microvesicles are lipid bilayer‐
encapsulated nanoparticles released by cells, ranging from 40 nm to several microns in …

Optimization of ultracentrifugation‐based method to enhance the purity and proteomic profiling depth of plasma‐derived extracellular vesicles and particles

Z Wan, J Gu, U Balaji, L Bojmar… - Journal of …, 2024 - Wiley Online Library
Circulating extracellular vesicles and particles (EVPs) are being investigated as potential
biomarkers for early cancer detection, prognosis, and disease monitoring. However, the …