Although it is known that the methylation of DNA in 5′ promoters suppresses gene
expression, the role of DNA methylation in gene bodies is unclear,,,,. In mammals, tissue …

DNA in somatic tissue is characterized by a bimodal pattern of methylation, which is
established in the animal through a series of developmental events 1. In the mouse blastula …

Processes that regulate gene transcription are directly under the influence of the genome
organization. The epigenome contains additional information that is not brought by DNA …

DNA in differentiated somatic cells has a fixed pattern of methylation, which is faithfully
copied after replication. By contrast, the methylation patterns of many tissue-specific and …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …

In an ideal world, biological processes would be understood at the molecular level by first
identifying all the participating components and then by deducing their roles in the system …

Is DNA methylation a key element in the regulation of vertebrate gene expression, or does it
play a minor part? There is support for both views in the recent literature, for while it is now …

It is likely that most vertebrate genes are associated with 'HTF islands'—DNA sequences in
which CpG is abundant and non-methylated. Highly tissue-specific genes, though, usually …

To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …

Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet
the rules that govern methylation patterns remain largely elusive. To gain insights into this …